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FLASH GENE
Symbol NUP88 contributors: mct/npt/pgu - updated : 06-07-2010
HGNC name nucleoporin 88kDa
HGNC id 8067
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil domain, an interaction domain often founded in NPC proteins
  • HOMOLOGY
    interspecies homolog to murine Prei2
    Homologene
    FAMILY Ezrin/radixin/moesin family
    CATEGORY structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nuclear envelope,pore
    text
  • localized on the spindles together with NUP214 during mitosis
  • localizes to the cytoplasmic and nuclear face of the nuclear pore complexes (
  • basic FUNCTION
  • having a dichotomous role in non-neoplastic and neoplastic conditions of the liver
  • its proper expression is critical for preventing aneuploidy formation and tumorigenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text birectional nucleocytoplastic transport
    PATHWAY
    metabolism
    signaling
    a component
  • nuclear pore complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding CAN/NUP214 and XPO1 (CRM1)
  • requested for NPC location
  • interacting with NFAT5 (up-regulated in response to hypertonic stress and acts to retain NFAT5 in the nucleus, activating transcription of critical osmoprotective genes)
  • binds lamin A (interaction is mediated by the N-terminus of NUP88, and NUP88 specifically binds the tail domain of lamin A but not of lamins B1 and B2)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in response to osmotic stress in inner medullary collecting duct (IMCD3) cells
    constitutional     --over  
    enhanced multinucleated cell formation
    tumoral     --over  
    in high-grade cervical intraepithelial neoplasia (CIN1) lesions and invasive squamous cell carcinoma compared with normal ectocervical squamous epithelia and CIN1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS