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FLASH GENE
Symbol PSMD1 contributors: mct - updated : 10-07-2018
HGNC name proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
HGNC id 9554
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
ten PC repeats
HOMOLOGY
Homologene
FAMILY proteasome subunit S1 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding
  • acting as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of
  • ubiquitinated proteins
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component 26 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
  • p112-L (105kDa) and p112-S (90kDa)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAPK14 negatively regulates the proteasome activity by phosphorylating Thr-273 of PSMD1
  • interaction of PSMD1 with ADRM1 is controlled by SUMOylation in a manner that may alter proteasome composition and function
  • PSMD1, ubiquitin, and the deubiquitylase UCHL5 bind to ADRM1 with independent energetics
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be a biomarker for age-related macular degeneration
  • Therapy target
    ANIMAL & CELL MODELS