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FLASH GENE
Symbol SOX12 contributors: mct - updated : 22-12-2015
HGNC name SRY (sex determining region Y)-box 12
HGNC id 11198
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA binding protein with an high mobility group (HMG) domain, C subfamily
  • a transactivation domain in the carboxyl terminus (transcription activation)
  • HOMOLOGY
    interspecies homolog to C.elegans t06e.11
    Homologene
    FAMILY
  • SRY-related HMG box family of transcription factor
  • SOXC family that includes SOX11 and SOX4
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • modulator of LINE retroposons promoter activity
  • TMED3 and SOX12 belong to different families involved in protein secretion and transcriptional regulation, but both promote endogenous WNT-TCF activity
  • TMED3 and SOX12 are required for efficient clonogenic behavior but only TMED3 for clone compaction
  • TMED3 and SOX12 have novel metastatic suppressive functions in human colon cancer cells
  • unlike TMED3, SOX12 is a multifunctional nuclear transcription factor that promotes CTNNB1/TCF activity
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component group C of Sry-related high-mobility group (HMG) box (Sox) transcription factors
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • FGFBP1 was a direct transcriptional target of SOX12
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    induced by FOXQ1 promotes hepatocellular invasion and metastasis by transactivating TWIST1 and FGFBP1 expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential prognostic biomarker in hepatocellular carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    novel therapeutic target for hepatocellular carcinoma
    ANIMAL & CELL MODELS
  • Sox12-deficient mice developed surprisingly normally, so that they were born alive, showed no gross phenotypic abnormalities, and were fertile in both sexes