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FLASH GENE
Symbol TMED10 contributors: mct - updated : 23-02-2012
HGNC name transmembrane emp24-like trafficking protein 10 (yeast)
HGNC id 16998
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a serine protease domain
  • a scavenger cysteine-rich domain
  • a LDL receptor class A domain
  • a GOLD domain
  • a transmembrane domain promoting its association with the presenilin complex that results in decreased gamma-cleavage activity
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Emp24p
    homolog to murine Tmed10 (92.2pc)
    homolog to rattus TMP21 (92.7pc)
    Homologene
    FAMILY
  • EMP24/GP25L family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,microsome
    text type I membrane protein; golgi cisternae
    basic FUNCTION
  • involved in vescular protein trafficking
  • differentially regulating gamma-secretase cleavage without affecting epsilon-secretase activity
  • transmembrane protein involved in endoplasmic reticulum/Golgi transpor
  • member of the p24 cargo-protein family that is involved in vesicular targeting and protein transport
  • presenilin complex component that modulates gamma- but not epsilon-secretase activities
  • behaves as a regulator of gamma- but not epsilon-cleavages generated by presenilin-dependent gamma-secretase complex
  • TMED2, TMED10 are specific cargo receptors of GPCRs and differentially control GPCR trafficking in the biosynthetic pathway, and thereby, TMED2 and TMED10 regulate GPCR signaling in astrocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of presenilin complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with gamma-secretase, and negatively regulates beta-amyloid production
  • interact with presenilin complexes
  • cell & other
    REGULATION
    Other degradation of TMED10, as with the other presenilin-associated gamma-secretase complex members, is mediated by the ubiquitin-proteasome pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in the brains of individuals with AD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    ability of the TMED10 peptide to alter APP processing and Abeta production could represent a novel strategy for modulating amyloid production and its subsequent pathology
    ANIMAL & CELL MODELS