SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,organelle,lumen
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic,microsome
|
text
| type I membrane protein; golgi cisternae |
basic FUNCTION
| involved in vescular protein trafficking |
|
differentially regulating gamma-secretase cleavage without affecting epsilon-secretase activity |
|
transmembrane protein involved in endoplasmic reticulum/Golgi transpor |
|
member of the p24 cargo-protein family that is involved in vesicular targeting and protein transport |
|
presenilin complex component that modulates gamma- but not epsilon-secretase activities |
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behaves as a regulator of gamma- but not epsilon-cleavages generated by presenilin-dependent gamma-secretase complex |
|
TMED2, TMED10 are specific cargo receptors of GPCRs and differentially control GPCR trafficking in the biosynthetic pathway, and thereby, TMED2 and TMED10 regulate GPCR signaling in astrocytes |