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FLASH GENE
Symbol MAGEA6 contributors: mct - updated : 20-05-2020
HGNC name melanoma antigen family A, 6
HGNC id 6804
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a MAGE domain
  • HOMOLOGY
    intraspecies homolog to MAGEA12/MAGEA2
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    text
  • MAGEA3, MAGEA4, MAGEA6,MAGEA8, are expressed in the undifferentiated human embryonic stem (hES) cells and early differentiated embryoid bodies (EBs) cells
  • basic FUNCTION
  • may play a role in tumor transformation or aspects of tumor progression
  • the frequencies of EPHA2 and MAGE6A-specific CD4+ T cells in cancerous patients were significantly correlated with active disease (AD) and gender of the patient (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • aberrant expression patterns of MAGEA6, in teratocarcinoma cells can be considered as specific teratocarcinoma biomarkers promoted the malignant phenotype
  • Therapy target
    ANIMAL & CELL MODELS