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FLASH GENE
Symbol MAGEA3 contributors: mct/npt - updated : 08-12-2009
HGNC name melanoma antigen family A, 3
HGNC id 6801
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a MAGE domain
  • HOMOLOGY
    interspecies homolog to C.elegans Y37E3.15
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a role in embryonal development and tumor transformation or aspects of tumor progression
  • acting as a tumor antigen
  • functional integrator of diverse signals, including FGFR2 and fibronectin, to modulate cancer progression (Liu 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense
    text
  • recognized on a melanoma by autologous cytolytic T
  • lymphocytes
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein target of the breast cancer risk factor fibroblast growth factor receptor 2 (FGFR2) (Liu 2008)
    cell & other
    REGULATION
    activated by MBD2 (up-regulate the basal activity of the promoter of MAGE proteins) (Wischniewski 2007)
    inhibited by FGFR2 (negatively regulated by FGFR2) (Zhu 2008)
    repressed by the TRD of MBD1 and MECP2 (Wischnewski 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, melanoma, advanced gastric carcinomas and hepatocellular carcinomas, squamous cell carcinoma of head and neck, malignant myeloma
    constitutional     --low  
    results in Tp53 transcriptional induction, also through reciprocal histone acetylation and methylation modifications (Zhu 2008)
    tumoral     --over  
    by promoter hypomethylation up-regulates its expression in colorectal carcinomas as well as in gastric cancers and might play a significant role in the development and progression of colorectal carcinomas (Kim 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene aberrant methylation patterns of MAGEs CpG islands using methylation-special PCRs may be useful for diagnosis of hepatocellular carcinoma
    Marker
    Therapy target
    ANIMAL & CELL MODELS