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FLASH GENE
Symbol XCL1 contributors: mct/npt - updated : 07-01-2013
HGNC name chemokine (C motif) ligand 1
HGNC id 10645
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • small inducible cytokine, retaining only two of the four cysteine of CC and CXC subfamilies
  • HOMOLOGY
    intraspecies homolog to XCL2
    Homologene
    FAMILY
  • small inducible cytokine, subfamily C
  • intercrine gamma family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • has chemotactic activity for lymphocytes but not for monocytes or neutrophils
  • utilizes highly specific glycosaminoglycan-binding sites that represent potential targets for drug development
  • XCL1 may support vascular inflammation by induction of release of interleukin 8 in polymorphonuclear neutrophils
  • regulate independent and distinct steps during transcription initiation and elongation
  • C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses
  • XCL1 and XCR1 are constitutively expressed in the thymus and regulate the thymic establishment of self-tolerance and the generation of regulatory T cells
  • role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation byhuman dendritic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with XCR1 (XC chemokine receptor-1)
  • AIRE-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
  • cell & other
    REGULATION
    induced by in peripheral blood mononuclear cells by mitogenic stimulation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in CD4+ and CD8+ T cells in Wegener granulomatosis
    constitutional     --low  
    associated with the suboptimal regulatory function of Treg in allergic asthma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • thymocytes from XCL1-deficient mice elicit dacryoadenitis in nude mice
  • Xcl1-deficient mice are defective in the medullary accumulation of thymic dendritic cells and the thymic generation of naturally occurring regulatory T cells (nT reg cells)