SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microfilament
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text
| cilia |
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AXIN1, TNKS2 and KIF3A are co-localized with SLC2A4 on the trans-Golgi network |
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during spermatogenesis KIF3A and KBP localized in the cytoplasm of round spermatids and manchette of elongating spermatids |
basic FUNCTION
| involved in anterograde transport of membranous organelles in the axon, distinct from synaptic vesicles |
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required to transport opsin and arrestin from the inner to the outer segment of phosphoreceptor |
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ciliary activity in early embryo putatively involved in the nodal flow supposed to break symetry |
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required for the maintenance of primary cilia (playing a role in maintaining the differentiation of lumen-forming epithelia |
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required for HH response |
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kinesin-2 complex (KIF3A, KIF3B) plays an important role not only in interphase but also in mitosis |
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play a role in subcellular transport of several cancer-relatedproteins, including the b-catenin–cadherin(s) complex |
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required for normal craniofacial patterning |
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involved in truncation of primary cilia causing a gain of Hedgehog function, and aberrant neural crest cell proliferation in the facial midline |
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regulates hair cell polarization through both ciliary and non-ciliary mechanisms |
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key component of the hair cell-intrinsic polarity machinery, which acts in concert with the tissue polarity pathway |
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in addition to its ciliogenic roles, KIF3A recruits DCTN1 to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres |
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is responsible for intraflagellar transport, which is required for protein delivery during axoneme formation in ciliated cells |
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essential role of KIF3A-mediated microtubular transport in the development of spermatozoa and male fertility |
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functions as an agonist of the Wnt signaling pathway in prostate cancer |
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midline cranial neural crest cells require KIF3A function in order to integrate and respond to Wnt signals from the surrounding epithelia |
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KIF3A, KIF3B (KIF3AB) is an N-terminal processive kinesin-2 family member best known for its role in intraflagellar transport |
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the kinesin-2 family motor KIF3A/KIF3B works together with dynein to bidirectionally transport intraflagellar particles, melanosomes, and neuronal vesicles |
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visual pigments transport to the retinal outer segment despite removal of KIF3A and IFT88, and KIF3A-mediated anterograde IFT88 is responsible for photoreceptor transition zone and axoneme formation |
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KIF17 and KIF3A do not act synergistically and did not prevent rhodopsin trafficking to rod outer segments |
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is required for the sperm tail formation and nuclear shaping during spermatogenesis |
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KIF3A, KIF3B, KIF3C is classified as a heterotrimeric kinesin-2 that is best known for organelle transport in neurons |
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is essential for glioblastoma multiforme (GBM) cell ciliogenesis, but its role in modulating GBM cell behavior is highly variable |
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anterograde intraflagellar transport motor protein, that regulates the integrity of primary cilia and various cellular functions |
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is important in the differentiation of dental follicle cells and human dental pulp cells through the Wnt pathway |
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plays a conserved role in photoreceptor outer segment formation and intracellular transport |