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FLASH GENE
Symbol SEPTIN8 contributors: SGE, mct - updated : 28-08-2019
HGNC name septin 8
HGNC id 16511
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ATP/GTP-binding site motif A (P loop)
  • conjugated PhosphoP
    mono polymer heteromer , oligo
    HOMOLOGY
    interspecies homolog to Drosophila melanogaster SEP2
    homolog to yeast S.cerevisiae CDC12
    homolog to murine Sept8 (98.4pc)
    Homologene
    FAMILY
  • GTP/GDP-binding proteins family
  • CATEGORY chaperone/stress , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,microtubule
    text localized surrounding alpha-granules
    basic FUNCTION
  • putative cytoskeletal protein required for cytokinesis and cellular morphogenesis
  • GTPase that assemble as filamentous scaffolds
  • involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking
  • may be playing a functional role in platelet granular secretion
  • playing a role in the development of proliferative retinal membranes
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heteroligomeric protein complex forming filaments
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP binding
  • protein
  • PNUTL1
  • SEPT5
  • interacting with CDK14, SEPT4, SEPT7
  • SEPT8 suppresses the interaction between VAMP2 and synaptophysin through binding to VAMP2
  • SEPTIN8 modulates likely bta-amyloidogenic processing of APP through a mechanism affecting the intracellular sorting and accumulation of BACE1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS