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FLASH GENE
Symbol CSRP1 contributors: - updated : 21-08-2007
HGNC name cysteine and glycine-rich protein 1
HGNC id 2469
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal cysteine rich LIM/double zinc finger motifs (LIM domains)
  • a glycine-rich repeat
  • HOMOLOGY
    interspecies homolog to murine Csrp
    Homologene
    FAMILY CSRP family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • expressed by a serum-inducible immediate response gene
  • likely involved in the determination of cell lineage and regulation of cell differentiation
  • being an essential factor that connects the noncanonical Wnt signals to cell behaviors and migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of complexes that control integrin-dependent cell migration of mesendoderm and cardiac mesoderm cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with ANKRD6 and DVL2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    loss of Csrp1 function results in cardiac bifida in the mouse