Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ACSL3 contributors: mct - updated : 11-10-2017
HGNC name acyl-CoA synthetase long-chain family member 3
HGNC id 3570
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
25-amino-acid consensus sequence,(FACs signature motif)
HOMOLOGY
interspecies homolog to murine Facl3
Homologene
FAMILY
  • long-chain-fatty-acid-coenzyme A ligase family
  • ATP-dependent AMP-binding enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • converting free long-chain fatty acid into fatty acyl-CoA esters
  • playing a role in lipid biosynthesis and fatty acid degradation
  • using preferentially myristate,laurate,arachidonate and eicosapentaenoate as substrates
  • involvement of ACSL4 and ACSL3 in insulin secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • magnesium Mg2+
  • AMP
  • protein
    cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS