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FLASH GENE
Symbol SH3GL2 contributors: mct - updated : 26-09-2015
HGNC name SH3-domain GRB2-like 2
HGNC id 10831
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative nuclear localization signal, potential tyrosine phosphorylation sites,
  • a Bin/Amphiphysin/Rvs (BAR) domain responsible for membrane bending, and an SH3 domain responsible for the recruitment of dynamin and synaptojanin, two proteins involved, respectively, in the fission and uncoating of clathrin-coated vesicles
  • putative SH2-, SH3-, and PTB-binding sites
  • C-terminal SH3 domain
  • HOMOLOGY
    intraspecies homolog to Src-homology 3 domain GRB2-like gene 2
    Homologene
    FAMILY endophilin family.
    CATEGORY adaptor , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text peripheral membrane protein. concentrated in presynaptic nerve terminals in neurons.
    basic FUNCTION
  • playing a role in synaptic vesicle recycling, in particular in clathrin-mediated vesicle endocytosis
  • novel function of postsynaptic SH3GL2 in spine morphogenesis, stabilization and synaptic function through the regulation of SRCIN1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component complexing with signalling molecules, including cell surface receptors, metalloprotease disintegrins and germinal centre kinase-like kinase (GLK)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with SYNJ1 and DNM1
  • PSD interacting with SH3GL2 that stimulates the catalytic activity of PSD on ARF6
  • SRCIN1, a regulator of cytoskeleton reorganization, is a downstream effector of SH3GL2 and disruption of their interaction impairs spine formation and maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS