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FLASH GENE
Symbol RALGDS contributors: mct - updated : 26-11-2010
HGNC name ral guanine nucleotide dissociation stimulator
HGNC id 9842
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal Ras-GEF domain
  • a Ras-GEF domain
  • C-terminal Ras-binding domain (RBD), necessary for the interaction with the broad C-terminal region (AA 141-595) of NF2
  • HOMOLOGY
    interspecies homolog to rattus Ralgds (86.8 pc)
    homolog to murine Ralgds (87.2 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • stimulating the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases
  • may be a key component in Ras-dependent carcinogenesis
  • acting as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap
  • downstream molecule of Ras, identified as a merlin-binding protein
  • plays a vital role in the regulation of Ral-dependent Weibel-Palade bodies (WPB) exocytosis after stimulation with Ca(2+)- or cAMP-raising agonists
  • with RALA participate in nutrient sensing and are indispensable for activation of mammalian target of rapamycin complex 1 (MTOR) induced by extracellular nutrients
  • with RGL2 and RGL3, can interact with activated Ras through their Ras Binding Domain (RBD), but may function as effectors for other Ras family members
  • crucial role in coupling activated Ras to activation of RAL, thus regulating several fundamental cell processes
  • Ras-interacting protein that are upregulated by hypertrophic stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    small GTPase mediated signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with R-Ras, H-Ras, K-Ras, and Rap
  • interacting with RIT1 and RIT2
  • direct interaction between merlin and RALGDS (merlin can function as a tumor suppressor by inhibiting the RALGDS-mediated oncogenic signals)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    of the RALGDS/RAL pathway promotes prostate cancer metastasis to bone
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS