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FLASH GENE
Symbol TMED1 contributors: mct - updated : 22-08-2014
HGNC name transmembrane emp24 protein transport domain containing 1
HGNC id 17291
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal extracytoplasmic region
  • a transmembrane domain
  • a GOLD domain
  • a short cytoplasmic tail
    • HOMOLOGY
    interspecies ortholog to murine Il1rl1l
    homolog to Drosophila CG9053
    Homologene
    FAMILY
  • EMP24/GP25L family
    • CATEGORY receptor membrane , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text type I transmembrane protein
    basic FUNCTION
  • leading to the activation of DNA binding by nuclear factor kappa-B (NFKB) or transcription from the IL8 promoter
  • TMED1 is required for optimal IL33-induced IL8 and IL6 production
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to interleukin 1 receptor-like 1 (IL1RL1)
  • TMED1 associates with IL1RL1 (interaction mediated by the GOLD domain of TMED1 and the TIR domain of IL1RL1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS