basic FUNCTION
| DNA repair by excision of UV induced DNA damage, putatively involved in photoreactivation |
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light-independent inhibitor of CLOCK-ARNTL (BMAL1) |
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involved in the negative limb of the feedback loop |
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regulate the functional activity of circadian transcriptional complex at the posttranslational level |
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involved in the negative limb of the feedback loop |
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negative regulators of the circadian clock, stronger than PER proteins |
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CRY1 expression was elevated during the night-day transition, when it reduced fasting gluconeogenic gene expression by blocking glucagon-mediated increases in intracellular cAMP concentrations and in the protein kinase A-mediated phosphorylation of CREB |
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essential clock component, displaying evening-time expression and serves as a strong repressor at morning-time elements (E box/E' box) |
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phase delay in CRY1 transcription is required for mammalian clock function |
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specific mechanism through which CRY1, CRY2 couple the activity of clock and receptor target genes to complex genomic circuits underpinning normal metabolic homeostasis |
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CRY1 alone is able to maintain cell-autonomous circadian rhythms, whereas CRY2 cannot |