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FLASH GENE
Symbol CASP4 contributors: shn/npt/pgu - updated : 02-06-2013
HGNC name caspase 4, apoptosis-related cysteine peptidase
HGNC id 1505
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal (Fas-associating protein with DEATH domain) FADD-like death effector domain
  • a conserved QACXG pentapeptide active site motif
  • mono polymer heteromer , dimer
    isoforms Precursor precursor producing two subunits,large and small,that dimerize
    HOMOLOGY
    interspecies homolog to mammalian interleukin 1 beta convertase (IL1BC)
    ortholog to Casp4, Mus musculus
    ortholog to Casp4, Rattus norvegicus
    ortholog to CASP4, Pan troglodytes
    Homologene
    FAMILY
  • cysteine-aspartic acid protease (caspase) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli
  • ocalized to the ER membrane
  • basic FUNCTION
  • involved in Fas-mediated apoptosis
  • cysteine containing aspartate-specific protease, potentially involved in procytokine activation
  • promoting apoptosis
  • a key mediator of apoptosis and inflammation in human retinal pigment epithelial cells
  • required for non-canonical inflammasome-triggered macrophage cell death, indicating that caspase-11 (CASP4) orchestrates both caspase-1-dependent and -independent outputs
  • a unique pro-inflammatory role for caspase-11 in the innate immune response to clinically significant bacterial infections
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • direct interaction of APBB1 and TSHZ3 with the promoter region of CASP4
  • RNA
    small molecule
    protein
  • cleaving and activating CASP1
  • NALP1
  • Caspase-14, CASP14 (Hu et al, 1998)
  • TNF receptor-associated factor 6, TRAF6
  • cell & other
    REGULATION
    inhibited by inhibitor 9, PI9
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • knock-down of CASP4 by siRNA reduces NF-kappaB activation and nuclear translocation
  • Casp11(-/-) mice, exhibited defects in IL-1&
  • 946; production and harboured a mutation in the Casp11 locus that attenuated caspase-11 expression
  • loss of caspase-11 rather than caspase-1 protected mice from a lethal dose of lipopolysaccharide