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FLASH GENE
Symbol AANAT contributors: mct - updated : 17-01-2009
HGNC name arylalkylamine N-acetyltransferase
HGNC id 19
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • acetyltransferase family
  • AANAT subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • penultimate step in melatonin synthesis, controlling its circadian rhythm production
  • modulating the function of the circadian clock in the supra optical nucleus and influencing activity and sleep
  • catalyze the acetylation of serotonin, a rate-limiting process in melatonin synthesis
  • controls daily changes in melatonin production by the pineal gland and thereby plays a unique role in biological timing in vertebrates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS circadian
    PATHWAY
    metabolism hormone
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • controlling the circadian rhythm of melatonin production
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to delayed sleep phase syndrome
    Variant & Polymorphism SNP significantly associated with the delayed sleep phase syndrome
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS