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FLASH GENE
Symbol HNRNPA1 contributors: mct/ - updated : 06-05-2015
HGNC name heterogeneous nuclear ribonucleoprotein A1
HGNC id 5031
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RNP (RRM), and RGG motifs
  • a M9 sequence functioning as a potent nuclear localization signal different from the basic NLS, and as a nuclear export signal
  • conjugated RiboP
    HOMOLOGY
    Homologene
    FAMILY
  • HNRP family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • cytoplasmic redistribution is a regulated process during viral infection and cellular stress
  • nucleocytoplasmic shuttling protein with roles in many aspects of mRNA metabolism
  • basic FUNCTION
  • packaging of premRNA into HnRNP particles and transport of polyA+ mRNA from nucleus to cytoplasm
  • HNRNPA1 preferentially binds TNPO1, TNPO2
  • may play a possible role in the mechanism of KRAS transcription
  • nucleocytoplasmic shuttling protein that regulates gene expression through its action on mRNA metabolism and translation
  • having a role as auxiliary factor that facilitate the processing of specific miRNAs
  • with HNRNPA2B1, and PTBP1, have critical role in promoting PKM2 production in tumours, and overexpression of some combination of them is, like PKM2 expression, likely to be a general phenomenon in cancer
  • with KHSRP have antagonistic roles in the post-transcriptional regulation of MIRLET7A1, MIRLET7A2, MIRLET7A3 expression
  • general RNA-binding protein having an inhibitory role in the RNASEN-mediated processing of MIRLET7As in cells that lack LIN28A, LIN28B expression
  • HNRNPA1, DMRT2 and POT1 act in concert to displace RPA1 from telomeric single-stranded DNA after DNA replication, and promote telomere capping to preserve genomic integrity
  • single-stranded oligonucleotide binding protein, that is thought to play a pivotal role in telomere maintenance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of heterogeneous nuclear RNA ribonucleoprotein complex
  • associated to premRNA in the nucleus
  • INTERACTION
    DNA binding to simple strand DNA
    RNA binding
    small molecule
    protein
  • binding to KPNB2 mediating the nuclear import of HNRPA1
  • HNRNPA1 recruitment to stress granules involves MKNK1/MKNK2-dependent phosphorylation of mRNA-bound HNRNPA1
  • binds specifically to the primary RNA sequence pri-miR-18a before Drosha (RNASEN) processing
  • negative regulator of MIRLET7A1, MIRLET7A2, MIRLET7A3
  • interacting with SMN2 (HNRNPA1 can inhibit splicing of SMN2 exon 7 by direct binding to the 3prime ss sequence)
  • HNRNPA1 and HNRNPF modulate the alternative splicing of exon 11 of the insulin receptor gene
  • MKNK1 regulates the phosphorylation and the subcellular distribution of HNRNPA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    constitutional     --over  
    lowering the level of secreted Abeta APP and may have a role in treating Alzheimer's disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS