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FLASH GENE
Symbol RAB7A contributors: mct - updated : 16-06-2016
HGNC name RAB7, member RAS oncogene family
HGNC id 9788
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal AAs of the RAB7A hypervariable C-terminal domain (HVD) are important for late endosomal/lysosomal localization, apparently due to their involvement in interaction with the RAB7A effector RAB-interacting lysosomal protein
  • HOMOLOGY
    interspecies homolog to murine Rab7
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    text
  • localizes primarily to acidic, pre-degradative and degradative organelles such as late endosomes, lysosomes, multivesicular bodies, phagosomes, autophagosomes and autophagolysosomes
  • STX7 colocalizes with RAB7A on late endosomes
  • an active, GTP-bound state that is membrane-bound and an inactive, GDP-bound state that is cytosolic
  • basic FUNCTION
  • GTPase, likely involved in vesicular transport of proteins from early to late endosomes and lysosomes
  • may be involved in the process of atherogenesis
  • implicated in the regulation of endocytic pathways
  • RAB7A and RILP are key proteins for the biogenesis of lysosomes and phagolysosomes
  • late endosome-/lysosome-associated small GTPase, playing critical roles in the endocytic processes
  • also plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses
  • plays a vital role in the regulation of the trafficking, maturation and fusion of endocytic and autophagic vesicles
  • specifically regulates transport, docking and fusion of late endosomes, autophagosomes and lysosomes and plays an important role in determining the fate of endocytic vesicles by regulating their fusion and subsequent degradation by lysosomes
  • novel role for SFTPA1 in modulating endolysosomal trafficking via RAB7A in primary alveolar macrophages (AM)
  • integral component of the signaling and trafficking scaffolds that assemble on the endosomal membrane and has been studied in the context of EGFR trafficking and down-regulation
  • RAB7A and TSG101 are required for the constitutive recycling of unliganded EGFRs via distinct mechanisms
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • interacting with OSBPL1A
  • regulates maturation of melanosomal matrix protein SILV
  • FYCO1 binds to both MAP1LC3A, PtdIns(3)P and RAB7A, and contains a domain responsible for microtubule plus end-dependent transport
  • simultaneously binds RILP and ORP1L to form a RILP-RAB7A-ORP1L complex
  • interacting with UVRAG, and RUBICON (GTP-bound RAB7A competes with UVRAG for RUBICON binding)
  • PLEKHF1 is involved in lysosomal sorting and induction of autophagosome formation via RAB7A signaling
  • ability of ATP6AP1 to guide lysosomal intracellular trafficking to the ruffled border, potentially through its interaction with the small GTPase RAB7A
  • TBC1D15 and TBC1D17 mediate proper autophagic encapsulation of mitochondria by regulating RAB7A activity at the interface between mitochondria and isolation membranes
  • NUMB and NUMBL interacted with small GTPase RAB7A to transition ERBB2 from early to late endosome for degradation
  • PLEKHM1 simultaneously binds RAB7A and ARL8B, bringing about clustering and fusion of late endosomes and lysosomes
  • inhibition of the GTPase activating protein TBC1D5 can enhance RAB7A activation and lead to a gain of function for retromer
  • NDFIP1 mediates the ubiquitination of NTRK2, resulting in receptor trafficking predominantly on RAB7A containing late endosomes, highlighting a pathway for NTRK2 degradation at the lysosome
  • AAMDC can interact with the RabGTPase-activating protein RABGAP1L, and AAMDC, RABGAP1L, and RAB7A colocalize in endolysosomes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS