basic FUNCTION
| eosinophil, basophil and dendritic cell, chemoattractant |
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putatively involved in eosinophil trafficking and other CCR3 mediated biological phenomena |
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involved in T lymphocyte |
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activation in the processus of allergy |
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ligand of CCR3 |
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CCL26, CCL24, CCL11 have the ability to regulate extravillous trophoblast (EVT) functions critical to their role in vessel remodelling, suggesting a new role for the eotaxin group of chemokines during placentation |
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CCL11, CCL24, and CCL26 are chemokines involved in the recruitment of eosinophils into tissues and that mainly activate CCR3 |
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blood-borne CCL11 may have important physiologic functions in the CNS and implicates the blood-brain barrier (BBB) as an important regulator of physiologic versus pathologic effects of CCL11 |
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is crucial in eosinophil chemoattraction and activation in asthma pathogenesis |
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CCL11, CCL24, and CCL26 all showed potent bactericidal activity, mediated through membrane disruption, against the airway pathogens Streptococcus pneumoniae, Staphylococcus aureus, Nontypeable Haemophilus influenzae, and Pseudomonas aeruginosa |
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eotaxins can contribute to host defense against common airway pathogens and that their activities are modulated by mast cell proteases |
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levels of CCL11 in plasma and CSF increase with age, and CCL11 suppresses adult neurogenesis in the central nervous system (CNS), resulting in memory impairment |
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role of CCL11 in osteoclast migration and resorption |