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FLASH GENE
Symbol SELENBP1 contributors: mct/pgu - updated : 24-10-2015
HGNC name selenium binding protein 1
HGNC id 10719
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Selenbp1
Homologene
FAMILY selenium-binding protein family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleolus
basic FUNCTION
  • may be involved in the initial sequential events in rapid cell outgrowth, such as determining direction of cell outgrowth and recruitment of actin monomer
  • implicated in selenium-dependent cell growth inhibition
  • may play a role in ubiquitination/deubiquitination-mediated protein degradation pathways in a selenium-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text intra Golgi protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    selenium Se2-
    protein
  • interacting with USP33 in a selenium-dependent manner
  • SELENBP1 and GPX1 form a physical association (interaction between two distinct selenium-containing proteins that may enhance the understanding of the mechanisms by which selenium and selenoproteins affect carcinogenesis)
  • SELENBP1 may likely negatively regulate astrocytic SELENOP synthesis and thereby limit downstream Se supply to neurons
  • cell & other
    REGULATION
    activated by by selenium treatment in the normal HOSE cells
    repressed by androgen
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    cortex of schizophrenic patient and in peripheral blood cells
    tumoral     --low  
    in ovarian cancer cells
    tumoral     --low  
    in liver tissues of patients with hepatocarcinoma (HCC)
    tumoral     --low  
    down-regulation may play a key role in the tumorigenic process of gastric carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potentially novel biomarker for prognosis of gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS