Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EYA3 contributors: mct - updated : 20-11-2018
HGNC name eyes absent homolog 3 (Drosophila)
HGNC id 3521
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminal large highly conserved domain,the eya homology domain,
  • a basic segment followed by an alpha helical domain composed of four successive hepta repeats forming a leucine zipper
  • HOMOLOGY
    interspecies homolog to Drosophila eyes absent gene (eya) 3,Dres67
    homolog to murine undetectable in embryo (E10,5;E12,5;E17,5)
    Homologene
    FAMILY
  • phosphatase subgroup of the haloacid dehalogenase-like (HAD)hydrolase superfamily
  • CATEGORY enzyme , regulatory , receptor membrane tyrosine phosphatase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be acting as a transcriptional activator and playing a role during development
  • participating directly in the modulation of cellular signaling through its phosphatase activity
  • threonine-phosphatase of EYA3 has likely a function distinct from that of the other EYAs
  • role for EYA3 in mediating tumor-associated immune suppression, suggesting that its inhibition may enhance checkpoint therapies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SKI is necessary for muscle terminal differentiation and it exerts this role, at least in part, through its association with SIX1 and EYA3 to regulate the MYOG transcription
  • EYA3 and its partner SIX1 synergistically activate TSHB expression (TSHB plays a key role in the pathway that regulates vertebrate photoperiodism)
  • WDR1 is an EYA3-specific substrate, which implies that EYA3 is a key modulator of the cytoskeletal reorganization
  • is a regulator of PPP2CA, a major cellular Ser/Thr phosphatase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS