| mouse heterozygous and homozygous for a targeted null mutation in Myoc gene are both viable and fertile, and Myoc is not required for normal intraocular pressure or normal ocular morphology ( | |
lenses of transgenic mice expressing the Human mutated Tyr437His myocilin developed nuclear cataracts, completely lost transparency, and eventually ruptured ( |
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Expression of human myocilin glaucomatous mutations in mouse eyes causes elevated intraocular pressure, which is a major phenotype of MYOC glaucoma ( |
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increased skeletal muscle mass in myocilin-expressing transgenic mice compared with wild-type mice |