| basic FUNCTION
| neurogenesis regulator D2, playing a role in neuronal differentiation |
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transcriptional activity |
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participating to NEUROD differentiation cascade during first trimester human placental development |
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essential for amygdala development  |
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possible redundant roles for NEUROD2 and NEUROD4 in pancreatic endocrine differentiation |
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induces transcription of neuronal genes and ZEB1, which in turn de-represses neuronal differentiation by down-regulating REST, and suppresses competing myogenic fate |
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regulate cell fate and neurite stratification in the developing retina |
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NEUROD2 is a key transcription factor that regulates the structural and functional differentiation of mossy fiber (MF) synapses |
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OLIG2 has the ability to permeate the cell membrane without the addition of a protein transduction domain (PTD), similar to other basic helix-loop-helix transcription factors such as MYOD1 and NEUROD2 |
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important function for NEUROD2 in balancing synaptic neurotransmission and intrinsic excitability and these processes are coordinated during cortical development |
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regulates STIM1 expression and store-operated calcium entry in cortical neurons |
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in newborn neurons, NEUROD2-mediated gene expression promotes differentiation, maturation, and survival |
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in postmitotic neurons also regulates synapse growth and ion channel expression to control excitability |
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is necessary to instruct a terminal differentiation program in basket cells that regulates targeted axon growth and inhibitory synapse formation |
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promotes the postnatal survival of both granule cells and molecular layer interneurons (basket and stellate cells |
