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FLASH GENE
Symbol NDUFA5 contributors: - updated : 17-10-2007
HGNC name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
HGNC id 7688
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal part with a putative beta sheet rich in hydrophobic AAs that may serve as mitochondrial import signal
  • C-terminal half of the protein having high potential to adopt a coiled-coil form
  • HOMOLOGY
    interspecies homolog to bovine
    homolog to rattus subunit B13
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION NADH ubiquinone oxidoreductase (Q reductase)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component alpha 5,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS