basic FUNCTION
| putative regulator of mineral phosphate homeostasis, likely by stimulation of phosphate uptake by the renal tubule |
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role in reproduction |
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could effectively prevent cytosolic Ca(2+) overload and protect cardiomyocytes from pathophysiological conditions such as in the failing heart |
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pro-apoptotic factor |
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regulates endothelial gene expression and modulates transendothelial migration of leukocytes, playing a critical role in transendothelial migration of inflammatory cells and being involved in the regulation of numerous aspects of endothelial function |
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STC1 expression downregulates prosurvival ERK1/2 signaling and reduces survival under conditions of oxidative stress |
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key regulator of superoxide generation in macrophages, suggesting that STC1 may profoundly affect the immune/inflammatory response |
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modulator or purinergic receptor signaling |
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promotes the expression of VEGF, and VEGF subsequently enhances tumor angiogenesis which in turn promotes the gastric tumor growth |
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endocrine regulator of gill Ca(2+) uptake during hypercalcemia |
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STC1, STC2 are known to be involved in tumor progression and metastasis |
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STC1 and STC2 play positive roles in angiogenic sprouting |
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is a proteinase inhibitor, suggesting a previously unrecognized function of STC1 in the IGF system |
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high expression level of STC1 in M1-polarized cells may serve as a negative mediator in inflammation |