Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol STC1 contributors: mct/npt/pgu - updated : 06-08-2016
HGNC name stanniocalcin 1
HGNC id 11373
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a motif containing a cysteine–serine dipeptide, which binds both ferrous (Fe2+) and ferric (Fe3+) heme, and with Cys114 being indispensible for binding
  • conjugated PhosphoP , Other
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Stc
    intraspecies paralog to STC2
    Homologene
    FAMILY
  • stanniocalcin family
  • CATEGORY regulatory , signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putative regulator of mineral phosphate homeostasis, likely by stimulation of phosphate uptake by the renal tubule
  • role in reproduction
  • could effectively prevent cytosolic Ca(2+) overload and protect cardiomyocytes from pathophysiological conditions such as in the failing heart
  • pro-apoptotic factor
  • regulates endothelial gene expression and modulates transendothelial migration of leukocytes, playing a critical role in transendothelial migration of inflammatory cells and being involved in the regulation of numerous aspects of endothelial function
  • STC1 expression downregulates prosurvival ERK1/2 signaling and reduces survival under conditions of oxidative stress
  • key regulator of superoxide generation in macrophages, suggesting that STC1 may profoundly affect the immune/inflammatory response
  • modulator or purinergic receptor signaling
  • promotes the expression of VEGF, and VEGF subsequently enhances tumor angiogenesis which in turn promotes the gastric tumor growth
  • endocrine regulator of gill Ca(2+) uptake during hypercalcemia
  • STC1, STC2 are known to be involved in tumor progression and metastasis
  • STC1 and STC2 play positive roles in angiogenic sprouting
  • is a proteinase inhibitor, suggesting a previously unrecognized function of STC1 in the IGF system
  • high expression level of STC1 in M1-polarized cells may serve as a negative mediator in inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism metal
    signaling
    mineral
    a component
  • 56 kDa homodimeric glycoprotein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • known regulator of angiogenesis, and target gene of WNT2 signaling in HUVEC down-regulated by WNT2 treatment
  • STC1 Cys114 is essential for hemin binding (heme bound to STC1 may have an impact on the redox balance of the cell, which becomes more evident under oxidative stress)
  • presence of native complexes between PAPPA and STC1, STC2 in the human ovary, indicating STC-mediated PAPPA proteolytic inhibition
  • STC1 may serve as a negative mediator to regulate inflammation, which might be associated with the expression of TBC1D3
  • cell & other
    REGULATION
    activated by histone hyper-acetylation and the recruitment of activated NFkappaB
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in primary breast tumor (with BRCA1)
    tumoral     --over  
    in ovarian cancer tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high expression of the STC1 gene might be a useful predictor of poor postoperative outcome in patients with colorectal cancer
  • Therapy target
    ANIMAL & CELL MODELS