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FLASH GENE
Symbol NDUFA1 contributors: mct - updated : 04-07-2009
HGNC name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
HGNC id 7683
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an hydrophobic N terminus
  • an hydrophilic C terminal domain
  • HOMOLOGY
    interspecies homolog to bovine MWFE (subunit of complex I essential for an active complex I)
    Homologene
    FAMILY
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text inner membrane, matrix side
    basic FUNCTION
  • NADH ubiquinone oxidoreductase (Q reductase)involved in the transport of electrons from NADH to ubiquinone
  • may also be phosphorylated and thus involved in complex I regulation (Potluri 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component component alpha 1, hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    INTERACTION
    DNA
    RNA
    small molecule
    protein interact with various mtDNA encoded complex I subunits (Potluri 2009)
    cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) NDUFA1D
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS