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FLASH GENE
Symbol SLC25A5 contributors: mct - updated : 22-05-2013
HGNC name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
HGNC id 10991
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three tandemly repeated mitochondrial carrier protein domains (SOLCAR repeats)
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Slc25a5
Homologene
FAMILY solute carrier family 25, mitochondrial, adenine nucleotide
CATEGORY transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
text
  • imports glycolytically produced ATP into the mitochondria
  • basic FUNCTION
  • ADP/ATP translocase, oxidative phosphorylation (OXPHOS), catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane
  • playing an important role in maintaining the cytosolic phosphorylation potential required for cell growth
  • linked to the rate of glycolytic metabolism, is an important indicator of carcinogenesis
  • not pro-apoptotic and may therefore contribute to carcinogenesis
  • is involved in memory formation or establishment, which could add mitochondrial processes to the wide array of pathways that regulate normal cognitive functions
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text energy transfer
    PATHWAY
    metabolism energetic , metal
    signaling
    a component
  • complexing with cyclophilin D (PPID and PPIF) at the inner mitochondrial membrane and voltage dependent anion selective channel(s) at the outer membrane, to form the mitochondrial permeability transition pore
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NF1 (nuclear factor 1) binds to two upstream elements of SLC25A5 promoter and actively represses expression of the gene in growth-arrested diploid skin fibroblasts
  • interacts with Fe-S apoproteins and MMS19 in the cytosolic Fe-S cluster assembly complex but not with the individual proteins
  • cell & other
    REGULATION
    repressed by nuclear factor-1 in growth-arrested human diploid cells
    ASSOCIATED DISORDERS
    corresponding disease(s) HARTS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in patients with non-syndromic ntellectual disability (ID) plus some additional features
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate for cancer therapy based on molecular targeting
  • Marker
    Therapy target
    ANIMAL & CELL MODELS