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FLASH GENE
Symbol PRKX contributors: mct/pgu - updated : 06-09-2010
HGNC name protein kinase, X-linked
HGNC id 9441
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a AGC-kinase C-terminal domain
  • a protein kinase domain
  • HOMOLOGY
    interspecies homolog to Drosophila DC2 kinase
    Homologene
    FAMILY
  • protein kinase superfamily
  • AGC Ser/Thr protein kinase family
  • cAMP subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may regulate epithelial morphogenesis during mammalian kidney development, and plays a role in cellular migration
  • can modulate the cAMP-mediated signal transduction pathway by preferential binding to the regulatory subunit type I (RIalpha) of cAMP-dependent protein kinase and by phosphorylating the type II regulatory subunit in the absence of cAMP
  • stimulates epithelial branching morphogenesis by activating cell migration and support a role for this kinase in the regulation of nephrogenesis and of collecting system development in the fetal kidney
  • with SMAD6 are required for PMA-induced cell attachment and spreading
  • signal-transduction protein required for macrophage differentiation
  • can restore normal function to PKD1-deficient kidneys and have implications for the development of preventative therapy for PKD1
  • cAMP-dependent kinase, regulator of epithelial morphogenesis during kidney development
  • stimulates endothelial cell proliferation, migration, and vascular-like structure formation, which are the three essential processes for angiogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to and phosphorylates Polycystin-1 (PKD1)
  • interacting with PKD1 and PIN1 (may mediate the function of PRKX in kidney development)
  • interaction of PRKX with PIN1, MAGI1 and BAG3 could contribute to the stimulating role of PRKX in angiogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    aberrant adult kidney expression in autosomal dominant polycystic kidney disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS