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Symbol AGTR2 contributors: mct - updated : 06-04-2020
HGNC name angiotensin II receptor, type 2
HGNC id 338
  • seven transmembrane segments (7TM) receptor
  • structures revealed an active-like conformation of the seven-transmembrane (7TM) helical bundle with a non-canonical positioning of the amphipathic helix VIII, potentially blocking recruitment of intracellular signaling partners
    interspecies ortholog to murine Agtr2
  • G-protein coupled receptor 1 family
  • CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localization of AGTR2 in the mitochondrial inner membrane
    basic FUNCTION
  • involved in blood pressure regulation
  • involved in the activation of dephosphorylating enzymes
  • stimulating a phosphotyrosine phosphatase which inhibits guanylate cyclase
  • involved in brain development and in trophic maintenance of cerebral neuronal connections
  • protecting from severe acute lung injury induced by acid aspiration or sepsis
  • AGTR1 and AGTR2, in the striatum exert an opposite effect on the modulation of dopamine synthesis rather than dopamine release
  • potential role in the cerebellar function
  • modulate mitochondrial respiration
  • AGTR1 and AGTR2 reciprocally regulate basal perfusion of muscle microvasculature
  • AGTR2 activity is required for normal microvascular responses to insulin
  • opposing effects of AGTR1 and AGTR2 on VEGF-driven angiogenesis converge on the regulation of activity of RHOA-ROCK-dependent endothelial cells migration
  • induce production of nitric oxide (NO), which may interact with ROS and modulate AGTR1 signaling
  • AGTR2-mediated effects may be implicated in the physiological maturation process of the heart
  • plays an important role in arterial pressure regulation and may modulate T cell activation and renal cytokine production during pregnancy
  • AGTR2 signaling positively regulates myoblast differentiation and potentiates skeletal muscle regenerative potential
  • may be involved in the control of sperm motility
  • plays a functional role in foetal development
  • AGTR2 on peripheral macrophages is a critical trigger for pain sensitization at the site of nerve injury
  • translocate to mitochondria and can contribute to reno-protective effects at early stages of diabetes
  • role of AGTR2 in improving lipid metabolism and preventing adiposity
    PHYSIOLOGICAL PROCESS cardiovascular , nervous system
    signaling hormonal
    a component
    small molecule
  • interacting with NR1H4 (upregulates AGTR2 expression at a transcriptional level and play a role in the NR1H4-mediated inhibition of ERK activation via upregulation of PTPN6)
  • plays a significant role in T3-induced cardioprotection
  • AGTR2 inhibits ligand-induced AGTR1 signaling through the PKC-dependent pathway
  • AGTR2 regulates TGFBR2 expression and function via the nitric oxide pathway, which may be important in the control of renal tubulointerstitial fibrosis
  • IRF1 is one of the key transcriptional factors for the prevention of neointimal formation involving AGTR1, AGTR2
  • cell & other
    corresponding disease(s) MRX88
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in mental retardation
    constitutional     --over  
    reduces enhanced collagen accumulation, MMP expression and activity in atherosclerotic regions via inhibition of pro-oxidant signals
    constitutional     --over  
    moderate cardiac-selective overexpression of AGTR2 protects heart function from ischaemic injury, which may be mediated, at least in part, through modulation of components of the cardiac renin-angiotensin system and collagen levels in the myocardium
    constitutional   deletion    
    in blood cells has a harmful effect on ischemic brain injury
    constitutional     --over  
    represents an endogenous protective pathway against vascular calcificationand its stimulation may efficiently reduce adverse cardiovascular events in patients with chronic kidney disease
    constitutional     --other  
    altered expression of AGTR1 and AGTR2 with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneration
    Susceptibility to preeclampsia
    Variant & Polymorphism
  • increasing the risk of preeclampsia
  • gender-specific association between AGTR2 polymorphism, kidney function and premature aging of the arterial tree in patients with type I diabetes
  • Candidate gene
    Therapy target
    diabetetype 1 
    targeted AGTR2 overexpression in renal cells may open new avenues to develop novel types of drugs preventing diabetic nephropathy
    AGTR2 antagonist showed effective analgesia for neuropathic pain
    AT2R agonism might represent a novel therapeutic strategy for patients with rheumatoid arthritis
    is a promising novel target gene for Bldder cancer gene therapy
    AGTR2 stimulation may be a new therapeutic approach to improve eating disorder associated with dopamine resistance
  • deletion of Agtr2 accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling
  • in female mice via potentially regulating estrogen may have protective role against Body weight gain and impaired glucose tolerance and lipid metabolism