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FLASH GENE
Symbol GLUD2 contributors: mct - updated : 15-03-2022
HGNC name glutamate dehydrogenase 2
HGNC id 4336
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • Glu/Leu/Phe/Val dehydrogenases family
  • CATEGORY adhesion , enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text localizes mainly to mitochondria and to a lesser extent to the endoplasmic reticulum of these cells
    basic FUNCTION
  • involved in the detoxification of transmitter glutamate
  • enzyme central to the metabolism of glutamate that also plays a role in cellular energetics
  • having importance for nerve tissue biology
  • in the kidney, could contribute to enhanced excretion of ammonia under acidosis
  • GLUD2 is not only an adhesion molecule at synapses but also works as a channel
  • role for GLUD1, GLUD2 at excitatory synapses in neuronal networks throughout the adult brain
  • synaptic connection in the adult brain can regenerate with aid of GLUD2
  • regulates synapse formation and regeneration, synaptic plasticity, and motor learning
  • CBLN1 and postsynaptic receptor GLUD2 mediate synaptogenesis between granule cells and Purkinje cells in the molecular layer of the cerebellar cortex
  • GLUD1 and GlUD2 exhibit the molecular architecture of postsynaptic ionotropic glutamate receptors, but assemble into trans-synaptic adhesion complexes by binding to secreted cerebellins that in turn interact with presynaptic neurexins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component CBLN1-GLUD2 complex is a unique synapse organizer that acts bidirectionally on both pre- and postsynaptic components
    INTERACTION
    DNA
    RNA
    small molecule
    protein CBLN1 binds directly to the N-terminal domain of GLUD2 (GLUD2 expression by postsynaptic cells, combined with exogenously applied CBLN1, was necessary and sufficient to induce new synapsesd in the adult cerebellum)
  • interactions between GLUD2 and DLG2 involve more than the extreme terminus of the receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to parkinson disease with earlier onset
    Variant & Polymorphism other a gain-of-function rare polymorphism modifies Parkinson disease onset
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS