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FLASH GENE
Symbol KDM5D contributors: SGE/npt - updated : 15-04-2010
HGNC name lysine (K)-specific demethylase 5D
HGNC id 11115
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one JMJN domain
  • one ARID domain
  • one JMJC domain
  • two PHD-type zinc fingers
  • one AT-rich interaction domain
  • isoforms Precursor a short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient
    HOMOLOGY
    interspecies homolog to chimpanzee JARID1D (99 pc)
    homolog to murine Kdm5d (81.3 pc)
    intraspecies paralog to HRBBP2
    Homologene
    FAMILY
  • JARID1 histone demethylase family
  • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • specifically demethylating trimethylated and dimethylated 'Lys-4' of histone H3 thereby playing a central role in histone code
  • may be involved in regulation of transcription, DNA-dependent
  • may play a role in spermatogenesis by recruiting a meiosis-specific protein to condensed DNA (Akimoto 2008)
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, chromatin organization, methylation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding, cofactor, other,
  • ascorbate
  • Fe2+
  • Zn2+
  • protein
  • interacting with PCGF6
  • complexing with MSH5 (Akimoto 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • HY-restricting antigen is associated with pregnancy outcome in patients with recurrent miscarriage subsequent to a firsborn boy (Nielsen 2009)
  • antibody responses to HY antigens correlate with chronic graft-versus-host disease and disease remission (Miklos 2005)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS