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FLASH GENE
Symbol GRIA3 contributors: mct/pgu - updated : 13-11-2013
HGNC name glutamate receptor, ionotrophic, AMPA 3
HGNC id 4573
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ligand binding site in the N terminal region
  • four transmembrane segments, one of which forming the wall of the channel
  • a large intracellular loop
  • HOMOLOGY
    interspecies homolog to murine Gria3
    Homologene
    FAMILY
  • ligand-gated ionic channels family
  • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • ligand gated ion (Cl) channel, mediating the fast component of excitatory post synaptic currents in the central nervous system
  • involved in neurite outgrowth, early neuronal cell development, neuropeptide signaling/synthesis and neuronal receptor
  • plays a role as a mediator of tumor progression in pancreatic cancer downstream CUX1
  • with GRIA2, GRIA1, GRIN2B, mediate fast synaptic transmission in the brain
  • role in the modulation of social behavior through brain dopamine and/or serotonin signaling and different AMPA receptor subunits affect social behavior through distinct mechanisms
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with and signaling through the protein-kinase LYN, PRKCABP
  • GRIA3 could be confirmed as a downstream effector of CUX1 and was expressed in pancreatic cancer tissues
  • interacting with GRIP1 and GRIP2 (bind to the C-termini of AMPA-R GRIA2 and GRIA3 subunits)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRXS29
    Susceptibility
  • to schizophrenia among females but not in males
  • to migraine with aura
  • Variant & Polymorphism other
  • carriers of rs1034428 A allele have a 2.19-fold higher risk of developing schizophrenia compared to non-carriers and 3.28-fold higher risk for developing a non-paranoid phenotype
  • GRIA3 (rs3761555) genes strongly associated with migraine with aura
  • Candidate gene
  • for X-linked mental retardation (severely reduced GRIA3 expression results in mental retardation)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking GluA1 showed a reduced anxiety and male aggression.