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FLASH GENE
Symbol GDI1 contributors: mct - updated : 16-10-2017
HGNC name GDP dissociation inhibitor 1
HGNC id 4226
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Gdi1 (98.0pc)
homolog to rattus Gdi1 (98.7pc)
Homologene
FAMILY
  • Rab GDI family
  • CATEGORY regulatory , signaling neurotransmitter , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in the regulation of vesicle-mediated cellular transport
  • involved in the regulation of neuronal differentiation and brain development (signal transduction)
  • regulating intracellular vesicle transport
  • regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them and the subsequent binding of GTP to them
  • GDI1 functions in the anchor cell (AC) to promote invadopodia formation
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development , cellular trafficking transport
    text intracellular vesicle transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of the switching mechanism that is required for commissural axons to change their response from attraction to repulsion at the intermediate target
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for presenilin 1 (PSEN1)
  • interacts with RAB10 in insulin-stimulated SLC2A4 translocation (Chen 2009)
  • interacting with RAC1 and involved in its inhibition (Papaharalambus 2005)
  • controls axonal midline crossing by regulating ROBO1 surface expression
  • GDI1 efficiently extracts RAC1 from liposomes preferentially in the inactive GDP-bound state
  • GDI1, PACSIN1, and DPYSL2 interact with not only phosphatidic acid (PA) but also with other phospholipids
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX41 , MRX48 , DUPXQ28
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in some ovarian cancers which are paclitaxel resistant (Goto 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    predictive marker for paclitaxel resistance in the treatment of ovarian cancers
    ANIMAL & CELL MODELS
  • Gdi1-null mice are impaired in attention and associative learning processes, which are a key part of the cognitive impairment observed in XLID patients