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FLASH GENE
Symbol CENPI contributors: mct/npt - updated : 27-02-2009
HGNC name centromere protein I
HGNC id 3968
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to S.pombe mis6
ortholog to rattus Fshprh1
ortholog to murine Fshprh1
Homologene
FAMILY
  • mis6 family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • involved in the response of gonadal tissue to FSH
  • constitutive protein of the kinetochore required for the localization of CENPF and the checkpoint proteins MAD1L1 and MAD2L1 to kinetochores (Liu 2003)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    text
  • spermatogenesis
  • female gamete generation
  • sex differentiation
  • PATHWAY
    metabolism
    signaling
    a component
  • constitutive centromere-associated network (CCAN) component (Hori 2008)
  • inner kinetochore component (may function, in part, as a marker directing CENPA deposition to centromeres)(Okada 2006)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS