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FLASH GENE
Symbol SSX4 contributors: mct/npt - updated : 25-03-2009
HGNC name synovial sarcoma, X breakpoint 4
HGNC id 11338
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a domain related to the KRAB domain of zinc finger proteins at the N terminus
  • a highly acidic C terminus
  • HOMOLOGY
    interspecies homolog to C.elegans t22c1.5
    intraspecies homolog to Krüppel associated box,KRAB
    Homologene
    FAMILY
  • SSX family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • acting as a modulator of transcription
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    rarely implicated in translocation t(X;18) in synovial sarcoma
    tumoral     --over  
    in melanomas (Ayyoub 2005)
    Susceptibility
    Variant & Polymorphism
    Candidate gene existence of CD4+ T cells specific for multiple SSX4 derived sequences in circulating lymphocytes from melanoma patients (Ayyoub 2005)
    Marker
    Therapy target
    ANIMAL & CELL MODELS