basic FUNCTION
| providing the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm |
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having distinct nucleic acid binding properties that act as a shuttle between the nucleus and the cytoplasm and acting on pre-mRNA to positively or negatively affect spliceosome assembly at nearby splice sites, thereby controlling pre-mRNA splicing |
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the relative levels of HNRNPF and HNRNPH2 in cells, as well as the target sequences in the downstream GRS (guanine-rich sequence) on pre-mRNA, influence gene expression |
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HNRNPH2/HNRNPF regulate genes that are involved in the transition from oligodendrocyte progenitor cells to oligodendrocytes |
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is a splicing regulator of TERF2 pre-mRNA that prevents the expression of TERF2-S, a factor implicated in neuronal differentiation |
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HNRNPH2, and HNRNPF have each been identified in neurons and are important in cellular proliferation, differentiation, and apoptosis |