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FLASH GENE
Symbol RBM3 contributors: mct - updated : 28-01-2015
HGNC name RNA binding motif protein 3
HGNC id 9900
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RNP (RRM) motif
  • one serine/arginine-glycine (SRGY) box in the C terminal region
  • HOMOLOGY
    interspecies ortholog to murine Rbm3
    homolog to C.elegans T12D8.2
    intraspecies homolog to RBM1,RBM2 (see symbols)
    homolog to YRRM (RBMY1A1)
    homolog to HNRPG
    Homologene
    FAMILY glycine-rich RNA-binding protein family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a formerly unknown role in the regulation of programmed cell death (apoptosis) in breast cancer
  • RNA stabilizing and translation regulatory protein RBM3 is a novel proto-oncogene that induces transformation when overexpressed and is essential for cells to progress through mitosis
  • is a critical factor providing cellular survival advantages in an adverse microenvironment presumably by restoring translation efficacy
  • is involved in hypothermia induced neuroprotection
  • RBM3 and CIRBP are two established cold-shock proteins
  • may have proliferative and/or proto-oncogenic functions in human astrocytomas
  • CIRBP and RBM3, are important regulators for the temperature entrained circadian gene expression
  • RBM3 has potentially a dual function: one as a chaperone protein that stabilizes mRNA transcripts and a second one in enhancing the transcription of ALPP and BGLAP genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • CIRBP and RBM3 regulated the circadian gene expression by controlling alternative polyadenylation (APA)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    associated with clinically more aggressive tumours and an independent factor of poor prognosis in patients with urothelial bladder cancer
    tumoral     --over  
    of RBM3 is an independent predictor of good prognosis in colorectal cancer
    constitutional     --over  
    decreases muscle cell necrosis as well as apoptosis and therefore RBM3 could potentially serve as an intervention for the loss of muscle cell viability during muscle atrophy and muscle diseases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rbm3(-/-) mouse embryonic fibroblasts (MEFs) showed poorer proliferation rates as compared to control MEFs, and have markedly increased number of G2-phase cells, suggesting a hitherto unknown role of RBM3 in the G2-phase control