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FLASH GENE
Symbol ZFX contributors: mct - updated : 25-10-2011
HGNC name zinc finger protein, X-linked
HGNC id 12869
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal acidic domain
  • a putative nuclear localization signal (NLS)
  • 13 zinc fingers in the C terminal region
  • HOMOLOGY
    interspecies homolog to rattus LOC367832
    homolog to murine Zfx
    Homologene
    FAMILY
  • krueppel c2h2-type zinc-finger protein family
  • zfx/zfy subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • shared transcriptional regulator of pluripotent embryonic stem cells (ESC) and hematopoietic SC (HSC),suggesting a common genetic basis of self-renewal in embryonic and adult stem cells
  • regulator of hematopoietic stem cell maintenance, in B-cell development and homeostasis
  • restrains the stress response and couples antigen receptor signaling to cell expansion and maintenance during B-cell development and peripheral homeostasis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in laryngeal squamous cell carcinoma, associated with its progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Zfx-deficient pluripotent embryonic SC (ESC) and hematopoietic SC (HSC)showed increased apoptosis and SC-specific upregulation of stress-inducible genes (