Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol STS contributors: mct/npt - updated : 27-01-2010
HGNC name steroid sulfatase (microsomal), isozyme S
HGNC id 11425
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • trypsin domain
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • sulfatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nuclear envelope
    text membrane-bound microsomal (Valle 2007)
    basic FUNCTION
  • desulphating a number of 3beta-hydroxysteroid sulphates
  • catalyzing the conversion of sulfated steroid precursors to estrogens during pregnancy
  • playing a crucial role in the intra-mitochondrial movement of cholesterol
  • may play a role in susceptibility for attention deficit hyperactivity disorder (Brookes 2008)
  • membrane-bound microsomal enzyme that hydrolyzes various alkyl and aryl steroid sulfates (Nardi 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 calcium ion per subunit
  • protein
  • increasing STAR protein expression level and stimulating steroid production
  • cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) SSDI , DELXPM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in endometrial carcinomas
    Susceptibility to attention deficit hyperactivity disorder (Brookes 2008)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS