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FLASH GENE
Symbol POLA1 contributors: mct/npt - updated : 11-06-2019
HGNC name polymerase (DNA directed), alpha 1, catalytic subunit
HGNC id 9173
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus (residues 1–337) is predicted to be poorly folded and does not participate in primer synthesis
  • a minimal MCM10 binding site to a small region within the N-terminal domain (residues 286-310)(Warren 2009)
  • a lysine-rich region that can directly interact with RNA
  • HOMOLOGY
    interspecies homolog to murine Pola1
    Homologene
    FAMILY
  • DNA polymerase type b family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • polymerase activity (DNA directed), alpha
  • is a critical regulator of the type I interferon response
  • plays an important role in genome replication
  • p180 catalytic subunit of DNA polymerase alpha-primase
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • POLA is composed of a 180-kDa catalytic subunit (p180) and a 70-kDa B subunit (p70)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between MCM10 and POLA1 (Chattopadhyay 2007)
  • interacts with the large subunit of primase
  • WDHD1 interacts with MCM10, which associates with MCM2-7, and with the p180 subunit of POLA
  • cell & other
    REGULATION
    Other phosphorylatedby CDK2/Cyclin A (may result in a conformational change in POLA2 facilitating its interaction with and activation by hyperphosphorylated retinoblastoma protein (ppRb)) (Takemura 2006)
    ASSOCIATED DISORDERS
    corresponding disease(s) PDRX , MRXS36
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    can enhance the association of generic mRNAs with the ER
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS