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FLASH GENE
Symbol PGK1 contributors: mct/npt - updated : 17-06-2020
HGNC name phosphoglycerate kinase 1
HGNC id 8896
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Pgk1
Homologene
FAMILY
  • phosphoglycerate kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphoglycerate kinase involved in glycolysis
  • key enzyme for ATP generation and energy pathway
  • might be a potential protein biomarker of intracellular oxidative status (Jang 2008)
  • PGK1 and PGK2 are involved in spermatogenesis and thought to be related to sperm motility
  • important dual roles of PGK1 as a glycolytic enzyme and a protein kinase in the mutual regulation of cell metabolism and autophagy in maintaining cell homeostasis
  • PGK1 catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP and produces 3-phosphoglycerate and ATP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDC7-bound PGK1 converts ADP to ATP, thereby abrogating the inhibitory effect of ADP on CDC7-ASK activity, promoting the recruitment of DNA helicase to replication origins, DNA replication, cell proliferation, and brain tumorigenesis
  • protein phosphatase activity of PTEN dephosphorylates and inhibits autophosphorylated PGK1, thereby inhibiting glycolysis, ATP production, and brain tumor cell proliferation
  • cell & other
    REGULATION
    induced by hydrogen peroxide
    ASSOCIATED DISORDERS
    corresponding disease(s) PGK1D
    related resource Retinal Information Network
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased in the testis with ageing
    tumoral     --over  
    leads to tumor cell proliferation
    tumoral     --over  
    is associated with poor prognosis in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker may serve as a promising biomarker for breast cancer
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    may serve as a promising target therapy for breast cancer
    ANIMAL & CELL MODELS