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FLASH GENE
Symbol MCF2 contributors: - updated : 31-12-2004
HGNC name MCF.2 cell line derived transforming sequence
HGNC id 6940
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH)
  • a DBL domains and a SH3 domain
  • a RhoGEF domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast Cdc24
    intraspecies homolog to Ascidian protein posterior End MARK2 (PEM2)
    Homologene
    FAMILY
    CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • GDP-GTP exchange factor for CDC42HS, specifically activating CDC42 and not RAC or RHOA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS