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FLASH GENE
Symbol EPHA1 contributors: mct - updated : 25-03-2014
HGNC name EPH receptor A1
HGNC id 3385
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single cysteine rich region
  • two FNIII domains in the extracellular region
  • C-terminal sterile alpha motif (SAM) domain is required and the ankyrin region of ILK is sufficient for the interaction between EPHA1 and ILK
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • Eph family
  • receptor tyrosine kinase, class VIII family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor tyrosine kinase
  • involved in short-range contact-mediated axonal guidance
  • EPHA1 signal facilitates IGF1-induced myogenesis by suppressing the RAS-ERK1/2 cascade through RASA1 in myoblast cell lines
  • may have roles in carcinogenesis and progression of prostate cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • regulates cell morphology and motility through the ILK-RHOA-ROCK pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    ATP
    protein
  • binding of EPHA1 to fibronectin through its type I repeat played an essential role in the angiogenesis
  • interaction between EPHA1 and ILK
  • HIC1 is a direct transcriptional repressor of EPHA1, a cell surface ligand implicated in the pathogenesis of epithelial cancers
  • cooperation between SLIT2 and EPHA1 regulates a balance between the pro- and antiangiogenic functions of SLIT2
  • ADAM12 enhanced EPHA1 cleavage in response to TGFB1 in primary tumors
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (HCC)
    tumoral     --low  
    epigenetic silencing of EPHA1 expression in colorectal cancer is correlated with poor survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    can be a potentially useful target for prognostic and therapeutic application
    ANIMAL & CELL MODELS