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FLASH GENE
Symbol SCP2 contributors: mct - updated : 13-07-2017
HGNC name sterol carrier protein 2
HGNC id 10606
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amino-terminal thiolase domain, and AA 1-32 amphipathic alpha-helical domain (cationic, positively charged face)
  • a carboxy-terminal sterol carrier protein 2 (SCP2) domain
  • isoforms Precursor encoded as a precursor protein (proSCP-2) (Martin 2008) N-terminal presequence in regulating SCP-2 structure, cholesterol localization within the ligand binding site, membrane association, and, potentially, intracellular targeting.
    HOMOLOGY
    interspecies homolog to murine Scp2 (89.2pc)
    homolog to rattus Scp2 (87.7pc)
    Homologene
    FAMILY
  • thiolase family
  • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,peroxisome
    text
  • cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues
  • isoform SCPx resides in the peroxisome
  • basic FUNCTION
  • SCPx isoform is a peroxisomal thiolase cleaving 2-methyl branched chains mediating intracellular cholesterol in steroidogenic tissues
  • facilitates cholesterol (Ch) and phospholipid (PL) transfer/exchange between membranes and appears to play a key role in intracellular lipid trafficking
  • playing a role in intracellular phosphatidylinositol transfer, distribution, and signaling
  • enhances cholesterol retention within the cell as well as regulates the distribution of signaling lipids, such as phosphoinositides and sphingolipids, at plasma membrane caveolae
  • FABP1 and SCP2 facilitate the preferential movement of HDL-associated cholesteryl esters (HDL-CEs) to bile for final elimination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text sterol carrier
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CAV1
  • cell & other
    REGULATION
    Other the two promoters can be upregulated by FOXO3A
    ASSOCIATED DISORDERS
    corresponding disease(s) DMN1
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS