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FLASH GENE
Symbol ALDH1B1 contributors: mct - updated : 08-10-2011
HGNC name aldehyde dehydrogenase 1 family, member B1
HGNC id 407
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 19-AA mitochondrial signal sequence at its N-terminus
  • mono polymer homomer , tetramer
    HOMOLOGY
    intraspecies homolog to ALDH1A1
    Homologene
    FAMILY aldehyde dehydrogenase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus
    basic FUNCTION
  • catalizing the propionaldehyde
  • catalyze the oxidation of endogenous and exogenous aldehydes to their corresponding acids
  • play a major role in the detoxification of alcohol-derived acetaldehyde
  • mitochondrial ALDH that metabolizes a wide range of aldehyde substrates including acetaldehyde and products of lipid peroxidation (LPO)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    dramatically upregulated in human colonic adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker potential biomarker for human colon cancer
    Therapy target
    ANIMAL & CELL MODELS