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FLASH GENE
Symbol RPL30 contributors: mct - updated : 26-12-2022
HGNC name ribosomal protein L30
HGNC id 10333
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to D8S1364E,likely
Homologene
FAMILY
  • ribosomal protein L30e family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    basic FUNCTION
  • 60S ribosomal protein L30
  • play an important role in p53 activation in response to nucleolar stress
  • RPL30 is a member of antimicrobial proteins (AMPs) which has ancient origin and is highly conserve throughout evolution
  • LONRF1, CDK1, RPL18, GNB2L1 (RACK1), RPL30, and SEC61A1 are crucial components in the diagnosis and treatment of Prostate carcinoma
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of ribosome, large subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in medulloblastoma is adversely associated with with adverse outcome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • reliable molecular biomarker for the diagnosis of prostate carcinoma
  • Therapy target
    ANIMAL & CELL MODELS