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FLASH GENE
Symbol MUC3A contributors: mct - updated : 23-10-2010
HGNC name mucin 3A, cell surface associated
HGNC id 7513
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal repetitive structures, one with an array of 20 short tandemly repeated structures, the second encoding a major serine/threonine domain
  • an extracellular cysteine-rich domain with 2 epidermal growth factor (EGF)-like motifs
  • a C terminal non repetitive mucin-like, a SEA (sea urchin sperm protein, enterokinase and agrin) module, with an intrinsic proteolytic site sequence G downward arrow SIVV (where G downward arrow S is the glycine serine cleavage site)
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY secretory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in epithelial cell protection
  • adhesion modulation and signaling
  • membrane-bound glycoprotein that is aberrantly expressed in carcinomas
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in several carcinomas
    Susceptibility Crohn's disease and ulcerative colitis
    Variant & Polymorphism
    Candidate gene
    Marker
  • methylation status of the MUC3A promoter may be a novel epigenetic marker for the diagnosis of carcinogenic risk and prediction of outcomes for cancer patients
    • Therapy target represents a potential novel therapeutic agent for intestinal wound healing
    ANIMAL & CELL MODELS