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FLASH GENE
Symbol CYP3A5 contributors: mct - updated : 29-03-2008
HGNC name cytochrome P450, family 3, subfamily A, polypeptide 5
HGNC id 2638
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
Homologene
FAMILY
  • cytochrome P450 subfamily IIIA
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • having an endogenous function related to the metabolism of intra-prostatic androgens and cell growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    drug including cyclosporine A ;metabolism of sex hormones
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    induced by glucocorticoids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Susceptibility to prostate cancer
    Variant & Polymorphism other polymorphisms affecting CYP3A5 activity may result in altered prostate cancer risk and aggressiveness.
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS