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FLASH GENE
Symbol DDC contributors: mct/npt - updated : 21-04-2010
HGNC name dopa decarboxylase (aromatic L-amino acid decarboxylase)
HGNC id 2719
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • pyridoxal-dependent decarboxylase conserved domain
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • pyridoxal-dependent aminotransferase superfamily
  • group II decarboxylase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • aromatic L-amino acid decarboxylase, required for the synthesis of dopamine and serotonine
  • pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-DOPA to dopamine (Kokkinou 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism amine
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • pyridoxal phosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DDC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    at the mRNA level, in the specimens from prostate cancer patients, in comparison to those from benign prostate hyperplasia patients (Avgeris 2008)
    Susceptibility to nicotine dependence
    Variant & Polymorphism other poymorphism increasing the risk of nicotine dependence
    Candidate gene potential of DDC expression, at the mRNA level, as a novel biomarker in prostate cancer (Avgeris 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS